{"id":93926,"date":"2023-06-27T23:17:42","date_gmt":"2023-06-28T06:17:42","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-neural-stem-cells-ipsc-derived-sod1-mutant-a4v-hom\/"},"modified":"2026-07-14T14:40:37","modified_gmt":"2026-07-14T21:40:37","slug":"human-neural-stem-cells-ipsc-derived-sod1-mutant-a4v-hom","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-neural-stem-cells-ipsc-derived-sod1-mutant-a4v-hom\/","title":{"rendered":"Human Neural Stem Cells (iPSC-derived, SOD1 mutant, A4V, HOM)"},"content":{"rendered":"

Product Description<\/strong><\/span><\/span><\/p>\n

Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. They primarily differentiate into neurons, astrocytes, and oligodendrocytes [1]<\/sup>. The recent discovery of induced pluripotent stem cells (iPSCs) not only overcomes the ethical and logistical issues associated with human embryonic stem cells, but also provides a flexible platform for generating various differentiated cell types from diseased individuals.iPSC-derived NSCs are a potentially valuable source of in vitro<\/em> models for complex, polygenic human diseases, and are potentially useful for drug discovery and cell-based therapy applications [2]<\/sup>.<\/p>\n

iXCells Biotechnologies <\/strong>provides high quality human neural stem cells (NSCs) derived from normal<\/a> or diseased iPS cell lines. These cells express typical markers of neural stem and progenitor cells, e.g. Nestin, Pax6 and Sox1 (Figure 1 and Figure 2), with the purity higher than 97% (Figure 3). The cells have been fully characterized for their self-renewal and multi-potency. The iPSC-derived NSCs can be differentiated into astrocytes or motor neurons (Figure 4). Cells can further expand for 3-5 passages in Human Neural Stem Cell Growth Medium (Cat# MD-0024), but they are not recommended for extensive expansion, because the purity of the neural stem cell population may decrease.<\/p>\n

All the cells provided by iXCells are negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C. The basic donor information (gender \/ age \/ race) is provided for each cell lot purchased.<\/p>\n

\"iPSC-derived<\/a><\/p>\n

Figure 1.<\/strong> iPSC-derived NSCs express Nestin and Pax6.<\/p>\n

\"iPSC-derived<\/p>\n

Figure 2.<\/strong> iPSC-derived NSCs express Nestin and Sox1.<\/p>\n

\"\"<\/p>\n

Figure 3.<\/strong> More than 97% of the NSCs are Nestin positive.<\/p>\n

\"\"<\/p>\n

Figure 4.<\/strong> iPSC-derived NSCs can be differentiated into GFAP+<\/sup> astrocyte (A) or HB9+<\/sup>motor neurons (B).<\/p>\n

Product Details<\/strong><\/p>\n\n\n\n\n\n\n\n\n
Tissue<\/strong><\/td>\nHuman Neural Stem Cells (iPSC-derived, SOD1 mutant, A4V, HOM)<\/td>\n<\/tr>\n
Package Size<\/strong><\/td>\n2 millioncells\/vial<\/td>\n<\/tr>\n
Shipped<\/strong><\/td>\nCryopreserved<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nLiquid nitrogen<\/td>\n<\/tr>\n
Growth Properties<\/strong><\/td>\nAdherent<\/td>\n<\/tr>\n
Media<\/strong><\/td>\nHuman Neural Stem Cell Growth Medium (Cat# MD-0024)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/span><\/strong><\/span><\/p>\n

[1] Alenzi, F; Bahkali, A (2011). “Stem cells: Biology and clinical potential”.African Journal of Biotechnology<\/em>10(86): 19929\u201340.<\/p>\n

[2] Dolmetsch R, Geschwind DH. (2011) \u201cThe human brain in a dish: the promise ofiPSC-derivedneurons\u201d. Cell<\/em>. 145(6):831-4.<\/p>\n

Datasheet & Culture Protocol<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Product Description Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. They primarily differentiate into neurons, astrocytes, and oligodendrocytes [1]. The recent discovery of induced pluripotent stem cells (iPSCs) not only overcomes the ethical and logistical issues associated with human embryonic stem cells, but also provides a […]<\/p>\n","protected":false},"featured_media":109449,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1835,1647],"product_tag":[2337,2328,2273,2330,2329,2272,2274,2327,2228,2275,2332,2336],"cell_type":[2418],"cell_system":[2426],"organ":[2439],"disease":[2459,2463],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-93926","product","type-product","status-publish","has-post-thumbnail","product_cat-diseases-modeling","product_cat-ipsc-ipsc-derived-cells","product_tag-a4v","product_tag-als","product_tag-als-cells","product_tag-als-engineered-cells","product_tag-als-gene-editing","product_tag-als-patient-derived","product_tag-amyotrophic-lateral-sclerosis","product_tag-amyotrophic-lateral-sclerosis-patient","product_tag-hom","product_tag-ipsc-als","product_tag-ipsc-derived","product_tag-sod1-mutant","cell_type-stem-cells","cell_system-nervous-system","organ-brain-central-nervous-system","disease-amyotrophic-lateral-sclerosis-als","disease-sod1-mutation-als-model","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"\nHuman Neural Stem Cells (iPSC-derived, SOD1 mutant, A4V, HOM) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-neural-stem-cells-ipsc-derived-sod1-mutant-a4v-hom\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Neural Stem Cells (iPSC-derived, SOD1 mutant, A4V, HOM) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description Neural stem cells (NSCs) are self-renewing, multipotent cells that generate the main phenotype of the nervous system. 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