{"id":74226,"date":"2023-05-22T05:43:19","date_gmt":"2023-05-22T12:43:19","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/rat-renal-mesangial-cells-rrmc\/"},"modified":"2023-07-20T06:28:15","modified_gmt":"2023-07-20T13:28:15","slug":"rat-renal-mesangial-cells-rrmc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/rat-renal-mesangial-cells-rrmc\/","title":{"rendered":"Rat Renal Mesangial Cells (RRMC)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Renal mesangial cells are perivascular cells located within the central portion of the glomerular tuft between capillary loops, constituting 30-40% of the total glomerular cell population [1]. They regulate the intraglomerular capillary flow and ultrafiltration surface via mesangial cell contraction and release of growth factors and vasoactive agents [2]. By pinocytosis and phagocytosis, mesangial cells remove local accumulation of macromolecules in the mesangial space [3]. Mesangial cells also synthesize, assemble and control turnover of the mesangial matrix. Overproduction of mesangial cells has been observed in various glomerular diseases, such as IgA nephropathy, mesangioproliferative glomerulonephritis, lupus nephritis, glomerulosclerosis and diabetic nephropathy [4]. Such critical involvements suggest renal mesangial cells are an ideal model for studying mesangial injury and glomerular functions under both physiological and pathophysiological conditions.<\/p>\n<p>iXCells Biotechnologies provides high quality Rat Renal Mesangial Cells (RRMC), which are isolated from postnatal day 2 rat kidney and cryopreserved at P1, with &gt;0.5 million cells in each vial. RRMC express fibronectin, Thy-1, and smooth muscle actin. They are negative for mycoplasma, bacteria, yeast, and fungi and can further expand for 5 population doublings in <a href=\"https:\/\/ixcellsbiotech.com\/product\/mesangial-cell-growth-medium\/\">Mesangial Cell Growth Medium (Cat# MD-0051) <\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"font-size: 14px; line-height: 22.4px; color: #ff8c00;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.8px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\">Tissue<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 20.8px;\"> Postnatal day 2 rat kidney<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\"> Package Size<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 20.8px;\"> 0.5 millioncells\/vial <\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\"> Passage Number<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 20.8px;\"> P1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\"> Shipped<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 20.8px;\"> Cryopreserved<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\"> Storage<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 20.8px;\"> Liquid nitrogen<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\"> Growth Properties<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 20.8px;\"> Adherent<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 20.8px;\"> Media<\/span><\/td>\n<td style=\"width: 592px;\"><a style=\"line-height: 20.8px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/mesangial-cell-growth-medium\/\">Mesangial Cell Growth Medium (Cat# MD-0051)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong style=\"font-size: 14px; line-height: 22.4px; color: #ff8c00;\">References<\/strong><\/p>\n<p>[1] Olivetti G, Anversa P, Rigamonti W, et al. (1977) J Cell Biol. 75(2 Pt 1):573-85.<\/p>\n<p>[2] Couchman JR, Beavan LA and McCarthy KJ. (1994) Kidney Int. 45:328-35.<\/p>\n<p>[3] Riser BL, Cortes P, Heilig C, et al. (1996) Am J Pathol. 148:1915-23.<\/p>\n<p>[4] Gruden G, Thomas S, Burt D, et al. (1999) J Am Soc Nephrol 10:730-37.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Renal mesangial cells are perivascular cells located within the central portion of the glomerular tuft between capillary loops, constituting 30-40% of the total glomerular cell population [1]. They regulate the intraglomerular capillary flow and ultrafiltration surface via mesangial [&hellip;]<\/p>\n","protected":false},"featured_media":99587,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74226","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rat Renal Mesangial Cells (RRMC) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/rat-renal-mesangial-cells-rrmc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rat Renal Mesangial Cells (RRMC) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Renal mesangial cells are perivascular cells located within the central portion of the glomerular tuft between capillary loops, constituting 30-40% of the total glomerular cell population [1]. 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