{"id":74222,"date":"2023-05-22T05:43:18","date_gmt":"2023-05-22T12:43:18","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/rat-pulmonary-fibroblasts-rpf\/"},"modified":"2023-07-20T06:35:05","modified_gmt":"2023-07-20T13:35:05","slug":"rat-pulmonary-fibroblasts-rpf","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/rat-pulmonary-fibroblasts-rpf\/","title":{"rendered":"Rat Pulmonary Fibroblasts (RPF)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>The most abundant cell type in the lung interstitium is the fibroblast. These fibroblasts resemble ordinary fibroblasts, but also possess some distinguishing features such as long, branching processes and gap junctions. Pulmonary fibroblasts function to produce type III collagen, elastin, and proteoglycans of the extracellular matrix of the alveolar septa. They play an important role in the repair and remodeling processes following tissue damage. The controlled accumulation of fibroblasts to sites of inflammation is crucial to effective tissue repair after injury [1]. An inadequate or an excessive accumulation of fibroblasts can result in abnormal tissue function. For example, excess proliferation of fibroblasts contributes to adventitial thickening observed during the development of hypoxia-induced pulmonary hypertension [2].<\/p>\n<p>iXCells Biotechnologies provides high quality Rat Pulmonary Fibroblasts (RPF), which are isolated from postnatal day 2 rat lung, and cryopreserved at P0, with &gt;0.5 million cells in each vial. RPF are characterized by fibroblast morphology and they are negative for mycoplasma, bacteria, yeast, and fungi. RPF can further expand for 5 population doublings in <a href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium (Cat# MD-0011)<\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"font-size: 14px; line-height: 22.4px; color: #ff8c00;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.8px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px; height: 29px;\">Tissue<\/td>\n<td style=\"width: 592px; height: 29px;\">Postnatal day 2 rat lung<\/td>\n<\/tr>\n<tr>\n<td>Package Size<\/td>\n<td style=\"width: 592px; height: 29px;\">0.5 millioncells\/vial<\/td>\n<\/tr>\n<tr>\n<td>Passage Number<\/td>\n<td>P0<\/td>\n<\/tr>\n<tr>\n<td>Shipped<\/td>\n<td>Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td>Growth Properties<\/td>\n<td>Adherent<\/td>\n<\/tr>\n<tr>\n<td>Media<\/td>\n<td><a href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium (Cat# MD-0011)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong style=\"font-size: 14px; line-height: 22.4px; color: #ff8c00;\">References<\/strong><\/p>\n<p>[1] Kuwano K, Hagimoto N, Hara N. (2001) Molecular mechanisms of pulmonary fibrosis and current treatment. Curr Mol Med 1(5):551-73.<\/p>\n<p>[2] Das M, Dempsey EC, Reeves JT, Stenmark KR. (2002) Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 282(5):L976-86. ScienCellResearch LaboratoriesTM<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description The most abundant cell type in the lung interstitium is the fibroblast. These fibroblasts resemble ordinary fibroblasts, but also possess some distinguishing features such as long, branching processes and gap junctions. Pulmonary fibroblasts function to produce type III [&hellip;]<\/p>\n","protected":false},"featured_media":99591,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74222","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rat Pulmonary Fibroblasts (RPF) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/rat-pulmonary-fibroblasts-rpf\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rat Pulmonary Fibroblasts (RPF) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description The most abundant cell type in the lung interstitium is the fibroblast. 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