{"id":74216,"date":"2023-05-22T05:43:17","date_gmt":"2023-05-22T12:43:17","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/rat-perineurial-fibroblasts-rpnf\/"},"modified":"2023-07-20T06:40:20","modified_gmt":"2023-07-20T13:40:20","slug":"rat-perineurial-fibroblasts-rpnf","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/rat-perineurial-fibroblasts-rpnf\/","title":{"rendered":"Rat Perineurial Fibroblasts (RPNF)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Perineurial fibroblasts are of mesenchymal origin and form the perineurium. The perineurium plays an important role in maintaining the integrity of the internal peripheral nerve environment by creating a physical barrier that, under physiologic condition, limits the entry of biologically active proteins, infectious agents, and blood-borne cells into the nerve bundles [1]. The perineurial fibroblasts are characterized by distinct ultrastructural features, including non-branching thin cytoplasmic processes coated by an external lamina and joined at their ends by a tight junction, few organelles, actin and vimentin filaments, and numerous pinocytotic vesicles [2]. Perineurial fibroblasts are initially recruited from the surrounding mesenchyme to form a loose, permeable sheath around axons and Schwann cells, where they are separated by the extracellular matrix. These cells later undergo a mesenchymal-to-epithelial transition to form tight junctions and organize into the perineurium. Perineurial fibroblasts are immunoreactive for vimentin and epithelial membrane antigen but not for the Schwann cell marker S-100 [3].<\/p>\n<p>iXCells Biotechnologies provides high quality Rat Perineurial Fibroblasts (RPNF), which are isolated from postnatal day 8 rat sciatic nerve and cryopreserved at P1, with &gt;0.5 million cells in each vial. RPNF express vimentin, S-100, GFAP and CD90. They are negative for mycoplasma, bacteria, yeast, and fungi and can further expand for 5 population doublings in <a href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium (Cat# MD-0011) <\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"font-size: 14px; line-height: 22.4px; color: #ff8c00;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.8px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px;\">Tissue<\/td>\n<td style=\"width: 592px;\">Postnatal day 8 rat sciatic nerve<\/td>\n<\/tr>\n<tr>\n<td>Package Size<\/td>\n<td style=\"width: 592px;\">0.5 millioncells\/vial<\/td>\n<\/tr>\n<tr>\n<td>Passage Number<\/td>\n<td>P1<\/td>\n<\/tr>\n<tr>\n<td>Shipped<\/td>\n<td>Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td>Storage<\/td>\n<td>Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td>Growth Properties<\/td>\n<td>Adherent<\/td>\n<\/tr>\n<tr>\n<td>Media<\/td>\n<td><a href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium (Cat# MD-0011)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong style=\"font-size: 14px; line-height: 22.4px; color: #ff8c00;\">References<\/strong><\/p>\n<p>[1] Salzer, J. L. (1999) Creating barriers: a new role for Schwann cells and desert hedgehog. Neuron 22:627629.<\/p>\n<p>[2] Erlandson, R. A. (1991) The enigmatic perineurial cell and its participation in tumors and in tumor like entities. Ultrastruct Pathol. 15:335-351.<\/p>\n<p>[3] Ariza, A., Bilbao, J. M. and Rosai, J. (1988) Immunohistochemical detection of epithelial membrane antigen in normal and perineurial cells and perineurioma. Am J Surg Pathol. 12:678-683.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Perineurial fibroblasts are of mesenchymal origin and form the perineurium. The perineurium plays an important role in maintaining the integrity of the internal peripheral nerve environment by creating a physical barrier that, under physiologic condition, limits the entry [&hellip;]<\/p>\n","protected":false},"featured_media":99593,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74216","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rat Perineurial Fibroblasts (RPNF) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/rat-perineurial-fibroblasts-rpnf\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rat Perineurial Fibroblasts (RPNF) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Perineurial fibroblasts are of mesenchymal origin and form the perineurium. 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