{"id":74190,"date":"2023-05-22T05:43:12","date_gmt":"2023-05-22T12:43:12","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/rat-dermal-fibroblasts-adult-rdf-a\/"},"modified":"2026-07-13T11:28:29","modified_gmt":"2026-07-13T18:28:29","slug":"rat-dermal-fibroblasts-adult-rdf-a","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/rat-dermal-fibroblasts-adult-rdf-a\/","title":{"rendered":"Rat Dermal Fibroblasts-Adult (RDF-a)"},"content":{"rendered":"<p><span style=\"font-size: 14px\"><span style=\"color: #ff8c00\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection to microinjection. In general, fibroblasts secrete a non-rigid extracellular matrix which is rich in type I and\/or type III collagen [1]. There is evidence showing that fibroblasts in different organs are intrinsically different [2]. Dermal fibroblasts switch from a proliferative, migratory phase to a contractile, matrix-remodeling phase during wound healing. In addition, they secrete large quantities of hyaluronan in response to inflammatory stimuli [3].<\/p>\n<p style=\"text-align: center\"><img decoding=\"async\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/06\/RDF-a-1.png\" alt=\"\" width=\"247\" height=\"184\" \/><\/p>\n<p align=\"center\"><strong>Figure 1. <\/strong>Rat Dermal Fibroblasts-Adult (RDF-a) (phase contrast)<\/p>\n<p>iXCells Biotechnologies provides high quality Rat Dermal Fibroblasts-Adult (RDF-a), which are isolated from adult rat skin and cryopreserved at P1, with &gt;0.5 million cells in each vial. RDF-a express fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 5 population doublings in <a href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium (Cat# MD-0011) <\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"font-size: 14px;line-height: 22.4px;color: #ff8c00\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.7999992370605px;width: 724px\" border=\"1\" width=\"724\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td>Tissue<\/td>\n<td>Adult rat skin<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\">Package Size<\/td>\n<td>0.5 millioncells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\">Passage Number<\/td>\n<td style=\"width: 592px\">P1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\">Shipped<\/td>\n<td style=\"width: 592px\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\">Storage<\/td>\n<td style=\"width: 592px\">Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\">Growth Properties<\/td>\n<td style=\"width: 592px\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\">Media<\/td>\n<td style=\"width: 592px\"><a href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium (Cat# MD-0011)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong style=\"font-size: 14px;line-height: 22.4px;color: #ff8c00\">References<\/strong><\/p>\n<p>[1] Conrad, G. W., Hart, G. W., Chen, Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26:119-137.<\/p>\n<p>[2] Gabbiani, G., Rungger-Brandle, E., The fibroblast. In Tissue Repair and Regeneration (L. E. Glynn, ed.), pp 1- 50. Handbook of Inflammation, Vol. 3. Amsterdam, Elsevier, 1981.<\/p>\n<p>[3] Stair S, Carlson KW, Shuster S, Wei ET, Stern R (2002) Mystixin peptides reduce hyaluronan deposition and edema formation. Eur J Pharmacol 30;450(3):291-6.<\/p>\n<p><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/07\/Rat-Dermal-Fibroblasts.pdf\" target=\"_blank\" rel=\"noopener\">Download Datasheet<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Product Description Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection [&hellip;]<\/p>\n","protected":false},"featured_media":90445,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[2417],"cell_system":[2431],"organ":[2445],"disease":[2454],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74190","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","cell_type-fibroblasts","cell_system-integumentary-system-skin-and-connective-tissue","organ-skin","disease-normal-healthy","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rat Dermal Fibroblasts-Adult (RDF-a) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/rat-dermal-fibroblasts-adult-rdf-a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rat Dermal Fibroblasts-Adult (RDF-a) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. 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