{"id":74119,"date":"2023-05-22T05:42:58","date_gmt":"2023-05-22T12:42:58","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/mouse-renal-mesangial-cells-mrmc\/"},"modified":"2023-07-28T06:43:06","modified_gmt":"2023-07-28T13:43:06","slug":"mouse-renal-mesangial-cells-mrmc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/mouse-renal-mesangial-cells-mrmc\/","title":{"rendered":"Mouse Renal Mesangial Cells (MRMC)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Renal mesangial cells are perivascular cells located within the central portion of the glomerular tuft between capillary loops, constituting 30-40% of the total glomerular cell population [1]. They regulate the intraglomerular capillary flow and ultrafiltration surface via mesangial cell contraction and release of growth factors and vasoactive agents [2]. By pinocytosis and phagocytosis, mesangial cells remove local accumulation of macromolecules in the mesangial space [3]. Mesangial cells also synthesize, assemble and control turnover of the mesangial matrix. Overproduction of mesangial cells has been observed in various glomerular diseases, such as IgA nephropathy, mesangioproliferative glomerulonephritis, lupus nephritis, glomerulosclerosis and diabetic nephropathy [4]. Such critical involvements suggest renal mesangial cells are an ideal model for studying mesangial injury and glomerular functions under both physiological and pathophysiological conditions.<\/p>\n<p>iXCells Biotechnologies provides high quality Mouse Renal Mesangial Cells (MRMC), which are isolated from postnatal day 2 mouse kidney and cryopreserved at P1, with &gt;0.5 million cells in each vial. MRMC express fibronectin, Thy-1, and smooth muscle actin. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 5 population doublings in <a href=\"https:\/\/ixcellsbiotech.com\/product\/mesangial-cell-growth-medium\/\">Mesangial Cell Growth Medium (Cat# MD-0051)<\/a>\u00a0under the condition suggested by iXCells Biotechnologies.<\/p>\n<p style=\"line-height: 20.7999992370605px;\"><strong style=\"color: #ff8c00; font-size: 14px; line-height: 22.3999996185303px;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.7999992370605px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px; height: 29px; vertical-align: middle;\"><strong><span style=\"color: #333333;\">Tissue<\/span><\/strong><\/td>\n<td style=\"width: 592px; height: 29px; vertical-align: middle;\"><span style=\"line-height: 18.9091px;\">Postnatal day 2 mouse kidney\u00a0(strain\u00a0C57BL\/6 or CD1)\u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px; height: 29px;\"><span style=\"color: #333333;\"><strong>Package Size<\/strong><\/span><\/td>\n<td style=\"width: 592px; height: 29px; vertical-align: middle;\"><span style=\"color: #333333;\">0.5 million cells\/vial \u00a0<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px; height: 29px;\"><span style=\"color: #333333;\"><strong>Passage Number<\/strong><\/span><\/td>\n<td style=\"width: 592px; height: 29px;\"><span style=\"color: #333333;\">P1<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px; height: 29px;\"><span style=\"color: #333333;\"><strong>Shipped<\/strong><\/span><\/td>\n<td style=\"width: 592px; height: 29px;\"><span style=\"color: #333333;\">Cryopreserved<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px; height: 29px;\"><span style=\"color: #333333;\"><strong>Storage<\/strong><\/span><\/td>\n<td style=\"width: 592px; height: 29px;\"><span style=\"color: #333333;\">Liquid nitrogen<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px; height: 29px;\"><span style=\"color: #333333;\"><strong>Growth Properties<\/strong><\/span><\/td>\n<td style=\"width: 592px; height: 29px;\"><span style=\"color: #333333;\">Adherent<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px; height: 29px;\"><span style=\"color: #333333;\"><strong>Media<\/strong><\/span><\/td>\n<td style=\"width: 592px; height: 29px;\"><a style=\"line-height: 18.9091px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/mesangial-cell-growth-medium\/\">Mesangial Cell Growth Medium (Cat# MD-0051)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: #ff8c00;\">References<\/span><\/strong><\/span><\/p>\n<p>[1] Olivetti G, Anversa P, Rigamonti W, Vitali-Mazza L, Loud AV. (1977) &#8220;Morphometry of the renal corpuscle during normal postnatal growth and compensatory hypertrophy. A light microscope study.&#8221; J Cell Biol. 75: 573-85.<\/p>\n<p>[2] Gruden G, Thomas S, Burt D, Zhou W, Chusney G, Gnudi L, Viberti G. (1999) \u201cInteraction of angiotensin II and mechanical stretch on vascular endothelial growth factor production by human mesangial cells.\u201d J Am Soc Nephrol. 10: 730-7.<\/p>\n<p>[3] G\u00f3mez-Guerrero C, Suzuki Y, Egido J. (2002) \u201cThe identification of IgA receptors in human mesangial cells: in the search for &#8220;Eldorado&#8221;.\u201d Kidney Int. 62: 715-7.<\/p>\n<p>[4] Abboud HE. (2012) \u201cMesangial cell biology.\u201d Exp Cell Res. 318: 979-85.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Renal mesangial cells are perivascular cells located within the central portion of the glomerular tuft between capillary loops, constituting 30-40% of the total glomerular cell population [1]. They regulate the intraglomerular capillary flow and ultrafiltration surface via mesangial [&hellip;]<\/p>\n","protected":false},"featured_media":108615,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74119","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mouse Renal Mesangial Cells (MRMC) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/mouse-renal-mesangial-cells-mrmc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mouse Renal Mesangial Cells (MRMC) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Renal mesangial cells are perivascular cells located within the central portion of the glomerular tuft between capillary loops, constituting 30-40% of the total glomerular cell population [1]. 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