{"id":74117,"date":"2023-05-22T05:42:58","date_gmt":"2023-05-22T12:42:58","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/mouse-pulmonary-fibroblasts-mpf\/"},"modified":"2026-07-10T11:12:13","modified_gmt":"2026-07-10T18:12:13","slug":"mouse-pulmonary-fibroblasts-mpf","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/mouse-pulmonary-fibroblasts-mpf\/","title":{"rendered":"Mouse Pulmonary Fibroblasts (MPF)"},"content":{"rendered":"

Product Description<\/strong><\/span><\/span><\/p>\n

The most abundant cell type in the lung interstitium is the fibroblast. These fibroblasts resemble ordinary fibroblasts, but also possess some distinguishing features, such as long, branching processes and gap junctions. Pulmonary fibroblasts function to produce type III collagen, elastin, and proteoglycans of the extracellular matrix of the alveolar septa. They play an important role in the repair and remodeling processes following tissue damage. The controlled accumulation of fibroblasts to sites of inflammation is crucial to effective tissue repair after injury [1]. An inadequate or an excessive accumulation of fibroblasts can result in abnormal tissue function. For example, excess proliferation of fibroblasts contributes to adventitial thickening observed during the development of hypoxia-induced pulmonary hypertension [2].<\/p>\n

iXCells Biotechnologies provides high quality Mouse Pulmonary Fibroblasts (MPF), which are isolated from postnatal day 2 C57BL\/6 mouse lung and cryopreserved at P1, with >0.5 million cells in each vial. MPF express fibronectin and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 5 population doublings in Fibroblast Growth Medium (Cat# MD-0011) <\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n

\"\"<\/p>\n

Figure 1.<\/b> Phase contrast image of primary Mouse Pulmonary Fibroblasts (MPF).<\/p>\n

Product Details<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Tissue<\/strong><\/td>\nPostnatal day 2 mouse lung (strainC57BL\/6 )<\/span><\/td>\n<\/tr>\n
Package Size<\/strong><\/td>\n0.5 millioncells\/vial<\/td>\n<\/tr>\n
Passage Number<\/strong><\/td>\nP1<\/td>\n<\/tr>\n
Shipped<\/strong><\/td>\nCryopreserved<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nLiquid nitrogen<\/td>\n<\/tr>\n
Growth Properties<\/strong><\/td>\nAdherent<\/td>\n<\/tr>\n
Media<\/strong><\/td>\nFibroblast Growth Medium (Cat# MD-0011)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/span><\/strong><\/p>\n

[1] Kuwano K, Hagimoto N, Hara N. (2001) \u201cMolecular mechanisms of pulmonary fibrosis and current treatment.\u201d Curr Mol Med. 1: 551-73.<\/p>\n

[2] Das M, Dempsey EC, Reeves JT, Stenmark KR. (2002) \u201cSelective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia.\u201d Am J Physiol Lung Cell Mol Physiol. 282: L976-86.<\/p>\n

Download Datasheet<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Product Description The most abundant cell type in the lung interstitium is the fibroblast. These fibroblasts resemble ordinary fibroblasts, but also possess some distinguishing features, such as long, branching processes and gap junctions. Pulmonary fibroblasts function to produce type III collagen, elastin, and proteoglycans of the extracellular matrix of the alveolar septa. They play an […]<\/p>\n","protected":false},"featured_media":108613,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[2417],"cell_system":[2427],"organ":[2440],"disease":[2454],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74117","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","cell_type-fibroblasts","cell_system-respiratory-system","organ-lung","disease-normal-healthy","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"\nMouse Pulmonary Fibroblasts (MPF) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/mouse-pulmonary-fibroblasts-mpf\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mouse Pulmonary Fibroblasts (MPF) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description The most abundant cell type in the lung interstitium is the fibroblast. 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