{"id":74101,"date":"2023-05-22T05:39:42","date_gmt":"2023-05-22T12:39:42","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/mouse-astrocytes-spinal-cord-ma-sc\/"},"modified":"2023-07-28T05:13:25","modified_gmt":"2023-07-28T12:13:25","slug":"mouse-astrocytes-spinal-cord-ma-sc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/mouse-astrocytes-spinal-cord-ma-sc\/","title":{"rendered":"Mouse Astrocytes-spinal cord (MA-sc)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Astrocytes are the major cell type in the mammalian brain. They have been implicated in a variety of supportive functions for their partner neurons in the CNS, such as neuronal guidance during development, ion and water homeostasis, blood flow regulation, neurotransmission, energy metabolism, and immune defense [1]. Recent studies have shown that spinal cord astrocytes contribute to neuroinflammation by chemokine expression which leads to the recruitment of \u201cinflammatory\u201d monocytes and neutrophils to the lesion site [2]. Experimentally, spinal cord astrocytes have also been used to study the wobbler mutation and muscular dystrophy in mice [3] and astrogliosis [4]. As the recognition of the importance of astrocytes in nervous system functioning is increasing, specifically regarding the modulation of neural activity, astrocyte cultures are continuing to provide a useful tool in exploring the diverse properties and functions of these cells.<\/p>\n<p>iXCells Biotechnologies provides high quality Mouse Astrocytes-spinal cord (MA-sc), which are isolated from neonate day two mouse spinal cord and cryopreserved at P1, with &gt;0.5 million cells in each vial. MA-sc express GFAP are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for 5 population doublings in <a href=\"https:\/\/ixcellsbiotech.com\/product\/astrocyte-medium\/\" target=\"_blank\" rel=\"noopener\">Astrocyte Medium (Cat# MD-0039) <\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"color: #ff8c00; font-size: 14px; line-height: 22.4px;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.7999992370605px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px; vertical-align: middle;\"><strong>Tissue<\/strong><\/td>\n<td style=\"width: 592px; vertical-align: middle;\">N<span style=\"line-height: 18.9091px;\">eonatal day two mouse spinal cord<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong>Package Size<\/strong><\/td>\n<td style=\"width: 592px; vertical-align: middle;\">0.5 million cells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong>Passage Number<\/strong><\/td>\n<td style=\"width: 592px;\">P1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong>Shipped<\/strong><\/td>\n<td style=\"width: 592px;\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong>Storage<\/strong><\/td>\n<td style=\"width: 592px;\">Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong>Growth Properties<\/strong><\/td>\n<td style=\"width: 592px;\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong>Media<\/strong><\/td>\n<td style=\"width: 592px;\"><a href=\"https:\/\/ixcellsbiotech.com\/product\/astrocyte-medium\/\" target=\"_blank\" rel=\"noopener\">Astrocyte Medium (Cat# MD-0039)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: #ff8c00;\">References<\/span><\/strong><\/span><\/p>\n<p>[1] Oberheim N, Goldman S, Nedergaard M. (2012) Heterogeneity of astrocytic form and function. Methods in Mol Biol. 814: 23-45.<\/p>\n<p>[2] Pineau I, Sun L, Bastien D, Lacroix S. (2010) Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor\/MyD88-depdent fashion. Brain Behav Immun. 24: 540-53.<\/p>\n<p>[3] Hantaz-Ambroise D, Blondet B, Murawsky M, Rieger F. (1994) Abnormal astrocyte differentiation and defective cellular interactions in wobbler mouse spinal cord. J Neurocytol. 23: 179-92.<\/p>\n<p>[4] Bhalala O, Pan L, Sahni V, McGuire T, Gruner K, Tourtellotte W, Kessler J. (2012) microRNA-21 regulates astrocytic response following spinal cord injury. J Neurosci. 32: 17935-47.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Astrocytes are the major cell type in the mammalian brain. They have been implicated in a variety of supportive functions for their partner neurons in the CNS, such as neuronal guidance during development, ion and water homeostasis, blood [&hellip;]<\/p>\n","protected":false},"featured_media":108574,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1632],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74101","product","type-product","status-publish","has-post-thumbnail","product_cat-animal-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mouse Astrocytes-spinal cord (MA-sc) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/mouse-astrocytes-spinal-cord-ma-sc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mouse Astrocytes-spinal cord (MA-sc) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Astrocytes are the major cell type in the mammalian brain. 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