{"id":74022,"date":"2023-05-22T05:39:26","date_gmt":"2023-05-22T12:39:26","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-schwann-cells-hswc\/"},"modified":"2026-07-08T14:24:35","modified_gmt":"2026-07-08T21:24:35","slug":"human-schwann-cells-hswc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-schwann-cells-hswc\/","title":{"rendered":"Human Schwann Cells (HSwC)"},"content":{"rendered":"<p style=\"line-height: 20.7999992370605px\"><span style=\"font-size: 16px\"><span style=\"color: #ff7300\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p style=\"text-align: justify\">Schwann cells are major type of glial cells in peripheral nervous system. Schwann cells differentiate from cells of the neural crest during embryonic development, and they are stimulated to proliferate by some constituent of the axonal surface. Schwann cells can be either myelinating or non-myelinating. Whilst myelinating Schwann cells wrap around the axons of motor and sensory neurons to form the myelin sheath, non-myelinating Schwann cells do not wrap around the axons but still provide support and cushioning to the unmyelinated axons <sup>[1]<\/sup>. Each myelinating Schwann cell wraps around the shaft of an individual peripheral axon, forming myelin sheaths along segments of the axon. When an axon is dying, the Schwann cells surrounding it aid in its digestion, leaving an empty channel formed by successive Schwann cells, through which a new axon may then grow from a severed end. The number of Schwann cells in peripheral nerves is tightly regulated <sup>[2]<\/sup>. Their proliferation <em>in vitro<\/em> can be stimulated by various growth factors including PDGF, FGF, neuregulin, and others <sup>[3]<\/sup>. Schwann cells provide a relatively simple, well-defined, and accessible mammalian model for the study of numerous developmental diseases. It is also of clinical importance to understand the biology of Schwann cells, not only in the context of neuropathies and nerve regeneration, but also because the cells or their precursors may be especially well suited for implants to facilitate repair in the CNS.<\/p>\n<p style=\"text-align: justify\"><strong>iXCells Biotechnologies<\/strong> provides high quality Human Schwann Cells (HSwC), which are isolated from human spinal nerve and cryopreserved at P1. Each vial contains \u22650.5 million viable cells. HSwC are characterized for expression of vimentin, S100, GFAP and CD90. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand no more than 3 passages in Schwann Cell Growth Medium (<a href=\"https:\/\/ixcellsbiotech.com\/product\/schwann-cell-growth-medium\/\">Cat# MD-0055<\/a>) under the condition suggested by iXCells Biotechnologies. Further expansion may decrease the purity.<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Human-Schwann-Cells-day1-day-3.jpg\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone\" style=\"width: 100%;height: auto;max-width: 1256px;margin: 0 auto;display: block\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Human-Schwann-Cells-day1-day-3.jpg\" alt=\"\" width=\"896\" height=\"334\" \/><\/a><\/p>\n<p style=\"text-align: left\"><strong>Figure 1.<\/strong> Human Schwann Cells (HSwC). The cells were recovered, and seeded at 10,000 cells\/cm<sup>2<\/sup> following iXCells\u2019 protocol. Phase contrast images were taken at the indicated time post recovery.<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Human-Schwann-Cells-Immunofluorescence-staining.jpg\"><img decoding=\"async\" class=\"alignnone\" style=\"width: 100%;height: auto;max-width: 1256px;margin: 0 auto;display: block\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Human-Schwann-Cells-Immunofluorescence-staining.jpg\" alt=\"\" width=\"896\" height=\"334\" \/><\/a><\/p>\n<p><strong>Figure 2.<\/strong> Immunofluorescence staining of HSwC with Antibody against S100b (Green). Nuclei was counterstained by DAPI (Blue).<\/p>\n<p style=\"line-height: 20.8px\"><span style=\"font-size: 16px\"><span style=\"color: #ff7300\"><strong>Product Details<\/strong><\/span><\/span><\/p>\n<table style=\"line-height: 20.8px;width: 1156px;height: 345px\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px\"><strong>Organism<\/strong><\/td>\n<td style=\"width: 592px\"><em>Homo Sapiens,<\/em> Human<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Cell Type<\/strong><\/td>\n<td style=\"width: 592px\">Glial Cell<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Tissue<\/strong><\/td>\n<td style=\"width: 592px\">Human Spinal Nerve<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Disease<\/strong><\/td>\n<td style=\"width: 592px\">Normal<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Package Size<\/strong><\/td>\n<td style=\"width: 592px\">0.5 x 10<sup>6 <\/sup>cells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Passage Number<\/strong><\/td>\n<td style=\"width: 592px\">P2<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Growth Properties<\/strong><\/td>\n<td style=\"width: 592px\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Product Format\/Shipped<\/strong><\/td>\n<td style=\"width: 592px\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Storage<\/strong><\/td>\n<td style=\"width: 592px\">Liquid Nitrogen<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Associated Media<\/strong><\/td>\n<td style=\"width: 592px\"><a style=\"line-height: 18.9091px\" href=\"https:\/\/ixcellsbiotech.com\/product\/schwann-cell-growth-medium\/\">Schwann Cell Growth Medium (Cat# MD-0055)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-size: 16px\"><strong><span style=\"color: #ff7300\">References<\/span><\/strong><\/span><\/p>\n<p>[1] Jessen, K. R. and Mirsky, R. (1999) Schwann cells and their precursors emerge as major regulators of nerve development. Trends Neurosci. 22:402-410.<\/p>\n<p>[2] Syroid, D. E., Maycox, P. R., Burrola, P. G., Liu, N., Wen, D., Lee, K. F., Lemke, G., Kilpatrick, T. J. (1996) Cell death in the Schwann cell lineage and its regulation by neuregulin. Proc. Natl. Acad. Sci. USA 93:9229-9234.<\/p>\n<p>[3] Rahmatullah, M., Schroering, A., Rothblum, K., Stahl, R. C., Urban, B and Carey, D. J. (1998) Synergistic regulation of Schwann cells proliferation by heregulin and forskolin. Mol. Cell. Biol. 18:6245-6252.<\/p>\n<p><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/10HU-188_2024.pdf\">Datasheet &amp; Culture Protocol\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Product Description Schwann cells are major type of glial cells in peripheral nervous system. Schwann cells differentiate from cells of the neural crest during embryonic development, and they are stimulated to proliferate by some constituent of the axonal surface. Schwann cells can be either myelinating or non-myelinating. Whilst myelinating Schwann cells wrap around the axons [&hellip;]<\/p>\n","protected":false},"featured_media":108798,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[2278,2277,2276,2279],"cell_type":[2420],"cell_system":[2426],"organ":[2439],"disease":[2454],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74022","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","product_tag-10hu-188","product_tag-hswc","product_tag-human-schwann-cells","product_tag-schwann-cells","cell_type-neurons-and-glial-cells","cell_system-nervous-system","organ-brain-central-nervous-system","disease-normal-healthy","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Schwann Cells (HSwC) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-schwann-cells-hswc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Schwann Cells (HSwC) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description Schwann cells are major type of glial cells in peripheral nervous system. 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