{"id":74010,"date":"2023-05-22T05:39:24","date_gmt":"2023-05-22T12:39:24","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-osteoblasts-osteoarthritis-hob-oa\/"},"modified":"2023-08-03T23:52:58","modified_gmt":"2023-08-04T06:52:58","slug":"human-osteoblasts-osteoarthritis-hob-oa","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-osteoblasts-osteoarthritis-hob-oa\/","title":{"rendered":"Human Osteoblasts-Osteoarthritis (HOb-OA)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Bone is a dynamic tissue, being continuously remodeled by the coordinated actions of osteoclasts and osteoblasts. Osteoblasts, the bone-forming cells, are derived originally from pluripotent mesenchymal stem cells. They synthesize and secrete organic extracellular matrix, osteoid, which is composed primarily of type I collagen. Osteoid is calcified by osteoblasts and during this process the cells become encased in lacunae within the calcified material and become osteocytes. Osteoblasts express protease-activated receptor-1 and vascular endothelial cell growth factor [1]. Studies show that leukemia inhibitory factor can bind to the osteoblast cell surface and induce bone formation both in vitro and in vivo [2]. The balance between osteoblast recruitment, proliferation, differentiation and apoptosis in sutures between cranial bones is essential for calvarial bone formation [3].<\/p>\n<p>iXCells Biotechnologies provides high quality Human Osteoblasts-Osteoarthritis (HOb-OA), which are isolated from bone of patients with osteoarthritis (OA) and cryopreserved at P2, with &gt;0.5 million cells in each vial. HOb-OA provide an excellent model system to study the pathophisiology of that disease in vitro, including matrix mineralization, effects of inflammatory mediators and bone morphogenic proteins, physiological control of bone remodeling and regulation of bone metabolism. HOb-OA are characterized by the cytochemical detection of AP and mineral deposition. These HOb-OA are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in <a style=\"line-height: 18.9091px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/osteoblast-growth-medium\/\">Osteoblast Growth Medium (Cat# MD-0054)<\/a>under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"color: #ff8c00; font-size: 14px; line-height: 22.4px;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.8px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\">Tissue<\/span><\/td>\n<td style=\"width: 592px;\">Bone of patients with osteoarthritis (OA)<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\"> Package Size<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 18.9091px;\"> 0.5 million cells\/vial <\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\"> Passage Number<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 18.9091px;\"> P2<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\"> Shipped<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 18.9091px;\"> Cryopreserved<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\"> Storage<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 18.9091px;\"> Liquid nitrogen<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\"> Growth Properties<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 18.9091px;\"> Adherent<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><span style=\"line-height: 18.9091px;\"> Media<\/span><\/td>\n<td style=\"width: 592px;\"><span style=\"line-height: 18.9091px;\"><a href=\"https:\/\/ixcellsbiotech.com\/product\/osteoblast-growth-medium\/\">Osteoblast Growth Medium (Cat# MD-0054)<\/a><\/span><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong style=\"color: #ff8c00; font-size: 14px; line-height: 22.4px;\">References<\/strong><\/p>\n<p>[1] Steinbrech, D. S., Mehrara, B. J., Saadeh, P. B., Greenwald, J.A., Spector, J. A., Gittes, G. K. and Longaker, M. T. (2000) VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism. Am. J. Physiol. Cell Physiol. 278: C853-C860.<\/p>\n<p>[2] Dazai, S., Akita, S., Hirano, A., Rashid, M. A., Naito, S., Akino, K., Fujii, T. (2000) Leukemia inhibitory factor enhances bone formation in calvarial bone defect. J. Craniofac. Surg. 11(6):513-20.<\/p>\n<p>[3] Marie, P. J., Debiais, F., Hay, E. (2002) Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling. Histol. Histopathol.17(3):877-85.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Bone is a dynamic tissue, being continuously remodeled by the coordinated actions of osteoclasts and osteoblasts. Osteoblasts, the bone-forming cells, are derived originally from pluripotent mesenchymal stem cells. They synthesize and secrete organic extracellular matrix, osteoid, which is [&hellip;]<\/p>\n","protected":false},"featured_media":99678,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-74010","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Osteoblasts-Osteoarthritis (HOb-OA) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-osteoblasts-osteoarthritis-hob-oa\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Osteoblasts-Osteoarthritis (HOb-OA) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Bone is a dynamic tissue, being continuously remodeled by the coordinated actions of osteoclasts and osteoblasts. 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