{"id":73922,"date":"2023-05-22T05:39:07","date_gmt":"2023-05-22T12:39:07","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-sertoli-cells-hserc\/"},"modified":"2026-07-27T06:25:07","modified_gmt":"2026-07-27T13:25:07","slug":"human-sertoli-cells-hserc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-sertoli-cells-hserc\/","title":{"rendered":"Human Sertoli Cells (HSerC)"},"content":{"rendered":"

Product Description<\/strong><\/span><\/span><\/p>\n

Human Sertoli Cells (HSerC) are essential for testicular development, spermatogenesis, and formation of the blood-testis barrier [1, 2]<\/sup>. HSerC limit the passage of substances such as hormones and nutrients to the adluminal compartment of the seminiferous tubules [1]<\/sup>. In addition to forming the blood-testis barrier, HSerC also provide the main structural support for the seminiferous tubules and protect the germ cells from the immune system [1]<\/sup>. Aberrant HSerC proliferation can contribute to the development of male reproductive disorders such as testicular germ-cell cancer, cryptorchidism, hypospadias, and low sperm count [2]<\/sup>. HSerC proliferation is in part controlled by follicle-stimulating hormone (FSH) and thyroid hormone (TH), where FSH drives proliferation and TH promotes a more quiescent state [3]<\/sup>. Cultured HSerC are a useful in vitro model to better understand testicular dysgenesis syndrome and to develop treatments for male reproductive disorders.<\/p>\n

iXCells Biotechnologies<\/strong> provides high quality HSerC, which are isolated from human testis and cryopreserved at P1, with \u2265 1.5 million cells in each vial. HSerC express GATA-4 and Sox-9 and are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. They can further expand for no more than 3 passages in Sertoli Cell Growth Medium (Cat# MD-0091<\/a>) under the condition suggested by iXCells Biotechnologies. Further expansion may decrease the purity.<\/p>\n

\"\"<\/a><\/p>\n

Figure 1.<\/strong> Human Sertoli Cells (HSerC). The cells were recovered, and seeded at 10,000 cells\/cm2<\/sup> following iXCells\u2019protocol. Phase contrast images were taken at the indicated time post recovery.<\/p>\n

\"\"<\/a><\/p>\n

Figure 2.<\/strong> Immunofluorescence staining of HSerC with antibody against Vimentin (Green). Nuclei were counterstained
\nby DAPI (Blue).<\/p>\n

Product Details<\/strong><\/span><\/span><\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n
Organism<\/strong><\/td>\nHomo Sapiens,<\/em> Human<\/td>\n<\/tr>\n
Cell Type<\/strong><\/td>\nEpithelial Supporting Cells<\/td>\n<\/tr>\n
Tissue<\/strong><\/td>\nHuman Testis<\/td>\n<\/tr>\n
Disease<\/strong><\/td>\nNormal<\/td>\n<\/tr>\n
Package Size<\/strong><\/td>\n1.5 x 106 <\/sup>cells\/vial<\/td>\n<\/tr>\n
Passage Number<\/strong><\/td>\nP1<\/td>\n<\/tr>\n
Growth Properties<\/strong><\/td>\nAdherent<\/td>\n<\/tr>\n
Product Format\/Shipped<\/strong><\/td>\nCryopreserved<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nLiquid Nitrogen<\/td>\n<\/tr>\n
Associated Media<\/strong><\/td>\nSertoli Cell Growth Medium(Cat# MD-0091)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/span><\/strong><\/span><\/p>\n

[1] Chui K, Trivedi A, Cheng C, Cherbavaz, Dazin P, Huynh A, Mitchell J, Rabinovich G, Noble-Haeusslein L, John C. (2011) “Characterization and functionality of proliferative human Sertoli cells.” Cell Transplant. 20(5): 619-635.<\/p>\n

[2] Sharpe R, McKinnell C, Kivlin C, Fisher J. (2003) “Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in adulthood.” Reproduction. 125: 769-784.<\/p>\n

[3] Tarulli G, Stanton P, Meachem S. (2012) “Is the adult Sertoli cell terminally differentiated” Biol Reprod. 87(1): 1-11.<\/p>\n

Datasheet & Culture Protocol\u00a0<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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