{"id":73912,"date":"2023-05-22T05:39:05","date_gmt":"2023-05-22T12:39:05","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-pulmonary-artery-adventitial-fibroblasts-hpaaf\/"},"modified":"2023-08-06T23:49:46","modified_gmt":"2023-08-07T06:49:46","slug":"human-pulmonary-artery-adventitial-fibroblasts-hpaaf","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-pulmonary-artery-adventitial-fibroblasts-hpaaf\/","title":{"rendered":"Human Pulmonary Artery Adventitial Fibroblasts (HPAAF)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of the easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection to microinjection. There is evidence showing that fibroblasts in various organs are intrinsically different [1]. Specifically, human pulmonary artery adventitial fibroblasts (HPAAF) are important modulators of vascular wall function [2]. During pathological conditions, such as hypoxia-induced pulmonary hypertension, HPAAF become proliferative which contributes to adventitial thickening [3].<\/p>\n<p>iXCells Biotechnologies provides high quality HPAAF, which are isolated from human pulmonary artery and cryopreserved at P1, with &gt;0.5 million cells in each vial. HPAAF express fibronectin and are characterized by their spindle-shaped morphology. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 16 population doublings in <a style=\"line-height: 18.9091px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium(Cat# MD-0011)<\/a> under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"color: #ff8c00; font-size: 14px; line-height: 22.4px;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.8px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td>Tissue<\/td>\n<td>H<span style=\"line-height: 18.9091px;\">uman pulmonary artery<\/span><\/td>\n<\/tr>\n<tr>\n<td><strong> Package Size<\/strong><\/td>\n<td>0.5 million cells\/vial<\/td>\n<\/tr>\n<tr>\n<td><strong> Passage Number<\/strong><\/td>\n<td>P1<\/td>\n<\/tr>\n<tr>\n<td><strong> Shipped<\/strong><\/td>\n<td>Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td><strong> Storage<\/strong><\/td>\n<td>Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td><strong> Growth Properties<\/strong><\/td>\n<td>Adherent<\/td>\n<\/tr>\n<tr>\n<td><strong> Media<\/strong><\/td>\n<td style=\"width: 592px; height: 29px;\"><a style=\"line-height: 18.9091px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/fibroblast-growth-medium\/\">Fibroblast Growth Medium(Cat# MD-0011)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: #ff8c00;\">References<\/span><\/strong><\/span><\/p>\n<p>[1] Conrad, G. W., Hart, G. W., Chen, Y. (1977) Differences in vitro between fibroblast-like cells from cornea, heart, and skin of embryonic chicks. J. Cell Sci. 26:119-137.<\/p>\n<p>[2] Pendurthi, U. R., Rao, L. V. M., Williams, J. T. and Idell, S. (1999) Regulation of tissue factor pathway inhibitor expression in smooth muscle cells. Blood 94:579-586.<\/p>\n<p>[3] Das M, Dempsey EC, Reeves JT, Stenmark KR. (2002) Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol 282(5):L976-86.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. They have been extensively used for a wide range of cellular and molecular studies as they are one of the easiest types of cells to grow in culture. Their [&hellip;]<\/p>\n","protected":false},"featured_media":99738,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-73912","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Pulmonary Artery Adventitial Fibroblasts (HPAAF) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-pulmonary-artery-adventitial-fibroblasts-hpaaf\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Pulmonary Artery Adventitial Fibroblasts (HPAAF) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Fibroblasts are mesenchymal cells derived from the embryonic mesoderm. 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