{"id":73830,"date":"2023-05-22T05:37:41","date_gmt":"2023-05-22T12:37:41","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-leydig-cells-hlc\/"},"modified":"2023-08-06T23:07:11","modified_gmt":"2023-08-07T06:07:11","slug":"human-leydig-cells-hlc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-leydig-cells-hlc\/","title":{"rendered":"Human Leydig Cells (HLC)"},"content":{"rendered":"

*** Product available by custom isolation only, please contact us to get a quote<\/a>. ***<\/strong><\/span><\/p>\n

Product Description<\/strong><\/span><\/span><\/p>\n

Human leydig Cells (HLC) are located in the interstitium of the testis near the seminiferous tubules [1, 2]. One of the main functions of HLC is to produce testosterone after stimulation by pituitary luteinizing hormone [1, 2, 3]. HLC<\/span>, through synthesis of testosterone, play a key role in mammalian sex determination by inducing differentiation of the Wolffian ducts into male reproductive organs [3]. Additionally, HLC produce insulin-like growth factor 3 which is required for scrotal descent of the testis [1]. Recent studies have indicated that molecules such as cyclic nucleotide phosphodiesterases can modulate testosterone production in HLC, suggesting that testosterone synthesis may be manipulated using pharmacological targeting [2]. Cultured HLC <\/span>are a useful in vitro model to better understand testicular development and to develop treatments for male reproductive disorders (Med para Hombres<\/a>).<\/p>\n

iXCells Biotechnologies provides high quality HLC, which are isolated from human testis and cryopreserved at P1, with >0.5 million cells in each vial. HLC express cytokeratin-18, and GATA-4. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 5 population doublings in Epithelial Cell Growth Medium (Cat# MD-0041)<\/a> under the condition suggested by iXCells Biotechnologies.<\/p>\n

Product Details<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Tissue<\/strong><\/td>\nHuman <\/span>testis<\/span><\/td>\n<\/tr>\n
Package Size<\/strong><\/td>\n0.5 million cells\/vial<\/td>\n<\/tr>\n
Passage Number<\/strong><\/td>\nP1<\/td>\n<\/tr>\n
Shipped<\/strong><\/td>\nCryopreserved<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nLiquid nitrogen<\/td>\n<\/tr>\n
Growth Properties<\/strong><\/td>\nAdherent<\/td>\n<\/tr>\n
Media<\/strong><\/td>\nEpithelial Cell Growth Medium (Cat# MD-0041)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

References<\/span><\/strong><\/span><\/p>\n

[1] Chen H, Ge R, Zirkin B. “Leydig cells: From stem cells to aging.” Mol Cell Endocrinol. 306(1-2): 9-16.<\/p>\n

[2] Vasta V, Shimizu-Albergine M, Beavo J. “Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A.” Proc Natl Acad Scie USA. 103(52): 19925-19930.<\/p>\n

[3] Lejeune H, Habert R, Saez JM. “Origin, proliferation and differentiation of Leydig cells.” J Mol Endocrinol. 20(1): 1-25.<\/p>\n","protected":false},"excerpt":{"rendered":"

*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Human leydig Cells (HLC) are located in the interstitium of the testis near the seminiferous tubules [1, 2]. One of the main functions of HLC is to produce testosterone after stimulation by pituitary luteinizing hormone [1, 2, 3]. 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