{"id":73820,"date":"2023-05-22T05:37:40","date_gmt":"2023-05-22T12:37:40","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-colonic-epithelial-cells-hcoepc\/"},"modified":"2026-06-18T15:09:22","modified_gmt":"2026-06-18T22:09:22","slug":"human-colonic-epithelial-cells-hcoepc","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-colonic-epithelial-cells-hcoepc\/","title":{"rendered":"Human Colonic Epithelial Cells (HCoEpC)"},"content":{"rendered":"<p style=\"line-height: 20.7999992370605px\"><span style=\"font-size: 14px\"><span style=\"color: #ff8c00\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>The colorectum is a major organ in both malignant and nonmalignant diseases. Cells that line the colonic mucosal surface form a major mechanical barrier that separates the host\u2019s internal milieu from the external environment. In addition to the well-established role of epithelial cells in ion transport, these cells appear to function as an integral component of the mucosal immune system. Human colonic epithelial cells (HCoEpC) can process and present antigens to T cells in vitro, and can be stimulated to express HLA class II and intercellular adhesion molecules in vivo [1]. They also respond to a broad array of cytokines with altered gene expression and growth characteristics [2]. In addition, normal colonic epithelial cells were found to express the \u03b13, \u03b15, \u03b16, \u03b21 and \u03b24 integrin [3].<\/p>\n<p>iXCells Biotechnologies provides high quality HCoEpC, which are isolated from human colonic tissue and cryopreserved at P1, with &gt;0.5 million cells in each vial. HCoEpC express cytokeratin-18 and -19. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in <a style=\"line-height: 18.9091px\" href=\"https:\/\/ixcellsbiotech.com\/product\/epithelial-cell-growth-medium\/\">Epithelial Cell Growth Medium (Cat# MD-0041)<\/a> under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"color: #ff8c00;font-size: 14px;line-height: 22.4px\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.7999992370605px;width: 724px\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px\"><strong>Tissue<\/strong><\/td>\n<td style=\"width: 592px\">H<span style=\"line-height: 20.8px\">uman <\/span><span style=\"line-height: 18.9091px\">colonic tissue<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Package Size<\/strong><\/td>\n<td style=\"width: 592px\">0.5 million cells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Passage Number<\/strong><\/td>\n<td style=\"width: 592px\">P1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Shipped<\/strong><\/td>\n<td style=\"width: 592px\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Storage<\/strong><\/td>\n<td style=\"width: 592px\">Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Growth Properties<\/strong><\/td>\n<td style=\"width: 592px\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Media<\/strong><\/td>\n<td style=\"width: 592px\"><a style=\"line-height: 18.9091px\" href=\"https:\/\/ixcellsbiotech.com\/product\/epithelial-cell-growth-medium\/\">Epithelial Cell Growth Medium (Cat# MD-0041)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 20.7999992370605px\"><span style=\"font-size: 14px\"><strong><span style=\"color: #ff8c00\">References<\/span><\/strong><\/span><\/p>\n<p>[1] Mayer, L., Eisenhardt, D., Salomon, P., Bauer, W., Plous, R. and Piccinini, L. (1991) Expression of class II molecules on intestinal epithelial cells in humans. Differences between normal and inflammatory bowel disease. Gastroenterology. 100:3-12.<\/p>\n<p>[2] Eckmann, L., Jung H.-C., Schuerer-Maly, C.-C., Panja, A., Morzycka-Wroblewska, E., and Kagnoff, M. F. (1993) Differential cytokine expression by human intestinal epithelial cell lines: regulated expression of interleukin-8. Gastroenterology. 105:1689-1697.<\/p>\n<p>[3] Stallmach, A., v Lampe, B., Matthes, H., Bornhoft, B., and Riecken, E. O. (1992) Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumor. Gut 33:342-346.<\/p>\n<p><img decoding=\"async\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/06\/pdf.jpg\" alt=\"\" width=\"30\" height=\"30\" \/><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/10HU-096_2025.pdf\">Download Datasheet<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Product Description The colorectum is a major organ in both malignant and nonmalignant diseases. Cells that line the colonic mucosal surface form a major mechanical barrier that separates the host\u2019s internal milieu from the external environment. In addition to the well-established role of epithelial cells in ion transport, these cells appear to function as an [&hellip;]<\/p>\n","protected":false},"featured_media":88422,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[],"cell_type":[2416],"cell_system":[2428],"organ":[2442],"disease":[2454],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-73820","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","cell_type-epithelial-cells","cell_system-digestive-and-gastrointestinal-system","organ-intestine-colon","disease-normal-healthy","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Colonic Epithelial Cells (HCoEpC) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-colonic-epithelial-cells-hcoepc\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Colonic Epithelial Cells (HCoEpC) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description The colorectum is a major organ in both malignant and nonmalignant diseases. 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