{"id":73770,"date":"2023-05-22T05:37:30","date_gmt":"2023-05-22T12:37:30","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-pancreatic-microvascular-endothelial-cells-hpamec\/"},"modified":"2026-06-17T15:01:03","modified_gmt":"2026-06-17T22:01:03","slug":"human-pancreatic-microvascular-endothelial-cells-hpamec","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-pancreatic-microvascular-endothelial-cells-hpamec\/","title":{"rendered":"Human Pancreatic Microvascular Endothelial Cells (HPaMEC)"},"content":{"rendered":"<p><span style=\"font-size: 16px\"><span style=\"color: #ff7300\"><strong>Product Overview<\/strong><\/span><\/span><\/p>\n<p>The pancreas functions as both an endocrine gland and a digestive organ, secreting hormones and producing pancreatic juice to aid in digestion.<sup>[1,2]<\/sup> The pancreatic islets, which serve as the endocrine component of the pancreas, produce essential hormones such as glucagon, insulin, and amylin <sup>[1,2]<\/sup>.\u00a0Human Pancreatic Microvascular Endothelial Cells (HPaMECs) play a critical role in supporting the islets by delivering oxygen and nutrients to pancreatic tissue, influencing beta cell function and proliferation, and regulating insulin gene expression during islet development. Additionally, HPaMECs produce various growth factors, optimize blood glucose sensing, and help regulate blood glucose levels. HPaMECs can serve as an in vitro model for studying islet biology, pancreatic cancer, transplantation, and regenerative medicine.<\/p>\n<p><strong>iXCells Biotechnologies <\/strong>provides high quality HPaMECs, which are isolated from human pancreas and cryopreserved at P2, with \u2265 0.5 million cells in each vial. These HPaMECs express von Willebrand Factor (vWF), VE-Cadherin and CD31\/PECAM-1. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi, and can be further expanded for no more than 3 passages under the conditions suggested by iXCells Biotechnologies. Further expansion may decrease the purity.<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Figure-1-Representative-bright-field-images-of-GABAergic-neurons-2.0.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone\" style=\"width: 100%;height: auto;max-width: 1256px;margin: 0 auto;display: block\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Phase-contrast-of-iXCells-Human-Pancreatic-Microvascular-Endothelial-Cells.jpg\" alt=\"\" width=\"896\" height=\"334\" \/><\/a><\/p>\n<p><strong>Figure 1.<\/strong>Phase contrast images of Human Pancreatic Microvascular Endothelial Cells (HPaMECs). The cells were recovered and seeded at 10,000 cells\/cm2 following iXCells\u2019 protocol. The images were taken at the indicated time post recovery.<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Figure-1-Representative-bright-field-images-of-GABAergic-neurons-2.0.png\"><img decoding=\"async\" class=\"alignnone\" style=\"width: 100%;height: auto;max-width: 1256px;margin: 0 auto;display: block\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Immunofluorescence-staining-of-iXCells-HPaMECs.jpg\" alt=\"\" width=\"896\" height=\"334\" \/><\/a><\/p>\n<p><strong>Figure 2.<\/strong>Immunofluorescence staining of HPaMECs using antibodies against VE-Cadherin (green), vWF (green) and CD31\/PECAM-1 (green) with nuclei counterstained by DAPI (blue).<\/p>\n<p style=\"line-height: 20.8px\"><span style=\"font-size: 16px\"><span style=\"color: #ff7300\"><strong>Product Details<\/strong><\/span><\/span><\/p>\n<table style=\"line-height: 20.8px;width: 1156px;height: 345px\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px\"><strong>Organism<\/strong><\/td>\n<td style=\"width: 592px\"><em>Homo Sapiens,<\/em> Human<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Cell Type<\/strong><\/td>\n<td style=\"width: 592px\">Endothelial Cells<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Tissue<\/strong><\/td>\n<td style=\"width: 592px\">Human Pancreas<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Disease<\/strong><\/td>\n<td style=\"width: 592px\">Normal<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Package Size<\/strong><\/td>\n<td style=\"width: 592px\">0.5 x 10<sup>6<\/sup> cells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Passage Number<\/strong><\/td>\n<td style=\"width: 592px\">P2<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Growth Properties<\/strong><\/td>\n<td style=\"width: 592px\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Product Format\/Shipped<\/strong><\/td>\n<td style=\"width: 592px\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Storage<\/strong><\/td>\n<td style=\"width: 592px\">Liquid Nitrogen<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong><span style=\"color: #ff8c00\"><span style=\"color: #ff7300\">References<\/span><\/span><\/strong><\/p>\n<p>[1] Zanone M, Favaro E, Camussi G (2008). \u201cFrom endothelial to beta cells: insights into pancreatic islet microendothelium.\u201d Curr Diabetes Rev. 4(1): 1-9.<br \/>\n[2] Konstantinova I and Lammert E. (2004). \u201cMicrovascular development: learning from pancreatic islets.\u201d Bioessays, 26(10):1069-1075.<\/p>\n<p><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/10HU-071_HPMEC_2024.pdf\">Datasheet &amp; Culture Protocol<\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Product Overview The pancreas functions as both an endocrine gland and a digestive organ, secreting hormones and producing pancreatic juice to aid in digestion.[1,2] The pancreatic islets, which serve as the endocrine component of the pancreas, produce essential hormones such as glucagon, insulin, and amylin [1,2].\u00a0Human Pancreatic Microvascular Endothelial Cells (HPaMECs) play a critical role [&hellip;]<\/p>\n","protected":false},"featured_media":90250,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[2360,2359,2358,2361],"cell_type":[2415],"cell_system":[2433],"organ":[2450],"disease":[2454],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-73770","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","product_tag-10hu-071","product_tag-hpamec","product_tag-human-pancreatic-microvascular-endothelial-cells","product_tag-human-primary-pancreatic-microvascular-endothelial-cells","cell_type-endothelial-cells","cell_system-endocrine-and-metabolic-system","organ-pancreas","disease-normal-healthy","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Pancreatic Microvascular Endothelial Cells (HPaMEC) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-pancreatic-microvascular-endothelial-cells-hpamec\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Pancreatic Microvascular Endothelial Cells (HPaMEC) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Overview The pancreas functions as both an endocrine gland and a digestive organ, secreting hormones and producing pancreatic juice to aid in digestion.[1,2] The pancreatic islets, which serve as the endocrine component of the pancreas, produce essential hormones such as glucagon, insulin, and amylin [1,2].\u00a0Human Pancreatic Microvascular Endothelial Cells (HPaMECs) play a critical role [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ixcellsbiotech.com\/product\/human-pancreatic-microvascular-endothelial-cells-hpamec\/\" \/>\n<meta property=\"og:site_name\" content=\"iXCells\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-17T22:01:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/10HU-071-1.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"750\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@iXCells\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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