{"id":73740,"date":"2023-05-22T05:37:24","date_gmt":"2023-05-22T12:37:24","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-colonic-microvascular-endothelial-cells-hcomec\/"},"modified":"2023-08-04T05:10:01","modified_gmt":"2023-08-04T12:10:01","slug":"human-colonic-microvascular-endothelial-cells-hcomec","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-colonic-microvascular-endothelial-cells-hcomec\/","title":{"rendered":"Human Colonic Microvascular Endothelial Cells (HCoMEC)"},"content":{"rendered":"<p style=\"text-align: center;\"><span style=\"font-size: 14pt;\"><strong>*** Product available by custom isolation only, please contact us to <a href=\"https:\/\/5176862.extforms.netsuite.com\/app\/site\/crm\/externalleadpage.nl\/compid.5176862\/.f?formid=8&amp;h=AAFdikaIHLKEukB9P_KfjbDOtxOZxhR8sm3tff5M3xp4lunfeUM&amp;redirect_count=1&amp;did_javascript_redirect=T\" target=\"_blank\" rel=\"noopener\">get a quote<\/a>. ***<\/strong><\/span><\/p>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><span style=\"color: #ff8c00;\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p>Endothelial cells lining the microvasculature are known to play a critical \u201cgatekeeper\u201d role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that intestinal microvascular endothelial cells exhibit a strong immune response to LPS challenge and play a critical regulatory role in gut inflammation [1]. Pharmacological inhibition of NOS in activated intestinal microvascular endothelial cells resulted in a significant increase in leukocytes binding [2]. Gene expression profile studies revealed that intestinal endothelial cells express biotinidase, which is involved in biotin recycling [3]. Human colonic microvascular endothelial cell (HCoMEC) cultures have enabled scientists to perform systematic analyses of cytokine profiles with regard to mRNA expression and protein secretion, and to compare these data with cytokine profiles from other endothelial cells.<\/p>\n<p>iXCells Biotechnologies provides high quality HCoMEC, which are isolated from human colonic tissue and cryopreserved at P1, with &gt;0.5 million cells in each vial. These HCerMEC express vWF\/Factor VIII, CD31 (PECAM), and Dil-Ac-LDL by uptake. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can further expand for 10 population doublings in <a style=\"line-height: 20.8px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/endothelial-cell-growth-medium\/\">Endothelial Cell Growth Medium (Cat# MD-0010)<\/a> under the condition suggested by iXCells Biotechnologies.<\/p>\n<p><strong style=\"color: #ff8c00; font-size: 14px; line-height: 22.4px;\">Product Details<\/strong><\/p>\n<table style=\"line-height: 20.8px; width: 724px;\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px;\"><strong>Tissue<\/strong><\/td>\n<td style=\"width: 592px;\">H<span style=\"line-height: 20.8px;\">uman colonic tissue<\/span><\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong> Package Size<\/strong><\/td>\n<td style=\"width: 592px;\">0.5 millioncells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong> Passage Number<\/strong><\/td>\n<td style=\"width: 592px;\">P1<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong> Shipped<\/strong><\/td>\n<td style=\"width: 592px;\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong> Storage<\/strong><\/td>\n<td style=\"width: 592px;\">Liquid nitrogen<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong> Growth Properties<\/strong><\/td>\n<td style=\"width: 592px;\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px;\"><strong> Media<\/strong><\/td>\n<td style=\"width: 592px;\"><a style=\"line-height: 20.8px;\" href=\"https:\/\/ixcellsbiotech.com\/product\/endothelial-cell-growth-medium\/\">Endothelial Cell Growth Medium (Cat# MD-0010)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p style=\"line-height: 20.7999992370605px;\"><span style=\"font-size: 14px;\"><strong><span style=\"color: #ff8c00;\">References<\/span><\/strong><\/span><\/p>\n<p>[1]. Ogawa, H., Rafiee, P., Heidemann, J., Fisher, P. J., Johnson, N. A., Otterson, M. F., Kalyanaraman, B., Pritchard, K. A. Jr., Binion, D. G. (2003) Mechanisms of endotoxin tolerance in human intestinal microvascular endothelial cells. J Immunol. 170(12):5956-64.<\/p>\n<p>[2]. Binion, D. G., Fu, S., Ramanujam, K. S., Chai, Y. C., Dweik, R. A., Drazba, J. A., Wade, J. G., Ziats, N. P., Erzurum, S. C. and Wilson, K. T. (1998) iNOS xpression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am. J. Physiol. 275:G592-603.<\/p>\n<p>[3]. Chi, J-T, Chang, H. Y., Haraldsen, G., Jahnsen, F. L., Troyanskaya, O. G., Chang, D. S., Wang, Z., Rockson, S. G., van de Rijn, M., Botstein, D. and Brown, P. O. (2003) Endothelial cell diversity revealed by global expression profiling. PNAS 100(19):10623-10628.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Endothelial cells lining the microvasculature are known to play a critical \u201cgatekeeper\u201d role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that intestinal microvascular endothelial cells [&hellip;]<\/p>\n","protected":false},"featured_media":99802,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[],"cell_type":[],"cell_system":[],"organ":[],"disease":[],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-73740","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","first","instock","taxable","shipping-taxable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Colonic Microvascular Endothelial Cells (HCoMEC) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-colonic-microvascular-endothelial-cells-hcomec\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Colonic Microvascular Endothelial Cells (HCoMEC) - iXCells\" \/>\n<meta property=\"og:description\" content=\"*** Product available by custom isolation only, please contact us to get a quote. *** Product Description Endothelial cells lining the microvasculature are known to play a critical \u201cgatekeeper\u201d role in the inflammatory process through their ability to recruit circulating immune cells into tissues and foci of inflammation. Studies show that intestinal microvascular endothelial cells [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ixcellsbiotech.com\/product\/human-colonic-microvascular-endothelial-cells-hcomec\/\" \/>\n<meta property=\"og:site_name\" content=\"iXCells\" \/>\n<meta property=\"article:modified_time\" content=\"2023-08-04T12:10:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/10HU-055.png\" \/>\n\t<meta property=\"og:image:width\" content=\"3264\" \/>\n\t<meta property=\"og:image:height\" content=\"2448\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@iXCells\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ixcellsbiotech.com\\\/product\\\/human-colonic-microvascular-endothelial-cells-hcomec\\\/\",\"url\":\"https:\\\/\\\/ixcellsbiotech.com\\\/product\\\/human-colonic-microvascular-endothelial-cells-hcomec\\\/\",\"name\":\"Human Colonic Microvascular Endothelial Cells (HCoMEC) - 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