{"id":73718,"date":"2023-05-22T05:37:20","date_gmt":"2023-05-22T12:37:20","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/product\/human-chondrocytes-articular-hc-a\/"},"modified":"2026-06-17T14:56:15","modified_gmt":"2026-06-17T21:56:15","slug":"human-chondrocytes-articular-hc-a","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-chondrocytes-articular-hc-a\/","title":{"rendered":"Human Chondrocytes-articular (HC-a)"},"content":{"rendered":"<p style=\"line-height: 20.7999992370605px\"><span style=\"font-size: 16px\"><span style=\"color: #ff7300\"><strong>Product Description<\/strong><\/span><\/span><\/p>\n<p style=\"text-align: justify\">Human chondrocytes are a specialized cell type with a highly developed cytoskeleton in human articular cartilage. Chondrocytes have a round or oval shape and occupy only 5\u201310% of the total cartilage volume <sup>[1]<\/sup>. These cells are primarily responsible for maintaining the biomechanical properties of cartilage and the extracellular matrix <sup>[2]<\/sup>. Mature chondrocytes produce essential structural proteins, including collagen types II, IX, and XI, as well as aggrecan. Articular chondrocytes also synthesize lubricin, which plays a crucial role in reducing friction between articulating cartilage surfaces. Since articular cartilage has a limited capacity for self-repair, chondrocytes are a focus of research on cartilage degeneration and regeneration in conditions such as osteoarthritis and rheumatoid arthritis.<\/p>\n<p style=\"text-align: justify\"><strong>iXCells Biotechnologies <\/strong>offers HC-a from human articular cartilage (Figure 1). These HC-a are Collagen II positive and Aggrecan positive (Figure 2). HC-a are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi. These cells can be maintained in Chondrocyte Medium (SKU: MD-0040) for at least 3 passages.<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Human-Chondrocytes-articular-HC-a-phase-contrast.png\"><img fetchpriority=\"high\" decoding=\"async\" class=\"alignnone\" style=\"width: 100%;height: auto;max-width: 1256px;margin: 0 auto;display: block\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Human-Chondrocytes-articular-HC-a-phase-contrast.png\" alt=\"\" width=\"896\" height=\"334\" \/><\/a><\/p>\n<p style=\"text-align: left\"><strong>Figure 1. <\/strong>Human Chondrocytes-articular (HC-a) (phase contrast).<\/p>\n<p style=\"text-align: center\"><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Figure-2.-HC-a-provided-by-iXCells.png\"><img decoding=\"async\" class=\"alignnone\" style=\"width: 100%;height: auto;max-width: 1256px;margin: 0 auto;display: block\" src=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Figure-2.-HC-a-provided-by-iXCells.png\" alt=\"\" width=\"896\" height=\"334\" \/><\/a><\/p>\n<p><strong>Figure 2.<\/strong> HC-a provided by iXCells are positive for Collagen II and Aggrecan, as shown by immunostaining.<\/p>\n<p style=\"line-height: 20.8px\"><span style=\"font-size: 16px\"><span style=\"color: #ff7300\"><strong>Product Details<\/strong><\/span><\/span><\/p>\n<table style=\"line-height: 20.8px;width: 1156px;height: 345px\" border=\"1\" cellspacing=\"1\" cellpadding=\"0\">\n<tbody>\n<tr>\n<td style=\"width: 132px\"><strong>Organism<\/strong><\/td>\n<td style=\"width: 592px\"><em>Homo Sapiens,<\/em> Human<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Cell Type<\/strong><\/td>\n<td style=\"width: 592px\">Chondrocytes<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Tissue<\/strong><\/td>\n<td style=\"width: 592px\">Human articular cartilage<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Disease<\/strong><\/td>\n<td style=\"width: 592px\">Normal<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Package Size<\/strong><\/td>\n<td style=\"width: 592px\">0.5 x 10<sup>6 <\/sup>cells\/vial<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Passage Number<\/strong><\/td>\n<td style=\"width: 592px\">P2<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Growth Properties<\/strong><\/td>\n<td style=\"width: 592px\">Adherent<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Product Format\/Shipped<\/strong><\/td>\n<td style=\"width: 592px\">Cryopreserved<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Storage<\/strong><\/td>\n<td style=\"width: 592px\">Liquid Nitrogen<\/td>\n<\/tr>\n<tr>\n<td style=\"width: 132px\"><strong>Associated Media<\/strong><\/td>\n<td style=\"width: 592px\"><a href=\"https:\/\/ixcellsbiotech.com\/product\/chondrocyte-medium\/\">Chondrocyte Medium (Cat# MD-0040)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><span style=\"font-size: 16px\"><strong><span style=\"color: #ff7300\">References<\/span><\/strong><\/span><\/p>\n<p style=\"text-align: justify\">[1] Ba\u010denkov\u00e1 D, Trebu\u0148ov\u00e1 M, Demeterov\u00e1 J, \u017div\u010d\u00e1k J. Human Chondrocytes, Metabolism of Articular Cartilage, and Strategies for Application to Tissue Engineering. Int J Mol Sci. 2023 Dec 4;24(23):17096. doi: 10.3390\/ijms242317096. PMID: 38069417; PMCID: PMC10707713.<\/p>\n<p>[2] Tallheden T, Brittberg M, Peterson L, Lindahl A. Human articular chondrocytes&#8211;plasticity and differentiation potential. Cells Tissues Organs. 2006;184(2):55-67. doi: 10.1159\/000098947. PMID: 17361078.<\/p>\n<div><a href=\"https:\/\/ixcellsbiotech.com\/wp-content\/uploads\/2023\/05\/Data-sheet_10HU-043.pdf\">Datasheet &amp; Culture Protocol<\/a><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Product Description Human chondrocytes are a specialized cell type with a highly developed cytoskeleton in human articular cartilage. Chondrocytes have a round or oval shape and occupy only 5\u201310% of the total cartilage volume [1]. These cells are primarily responsible for maintaining the biomechanical properties of cartilage and the extracellular matrix [2]. Mature chondrocytes produce [&hellip;]<\/p>\n","protected":false},"featured_media":99405,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[2351,2354,2352,2353],"cell_type":[2422],"cell_system":[2430],"organ":[2446],"disease":[2454],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-73718","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","product_tag-10hu-043","product_tag-hc-a","product_tag-human-chondrocytes-articular","product_tag-human-chondrocytes-articular-hc-a","cell_type-connective-tissue-and-structural-cells","cell_system-musculoskeletal-system","organ-bone-cartilage-joint","disease-normal-healthy","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Human Chondrocytes-articular (HC-a) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-chondrocytes-articular-hc-a\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Chondrocytes-articular (HC-a) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description Human chondrocytes are a specialized cell type with a highly developed cytoskeleton in human articular cartilage. 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