{"id":122502,"date":"2026-08-24T15:13:59","date_gmt":"2026-08-24T22:13:59","guid":{"rendered":"https:\/\/ixcellsbiotech.com\/?post_type=product&p=122502"},"modified":"2026-08-28T11:15:20","modified_gmt":"2026-08-28T18:15:20","slug":"human-fibroblast-like-synoviocytes-osteoarthritis-hfls-oa","status":"publish","type":"product","link":"https:\/\/ixcellsbiotech.com\/product\/human-fibroblast-like-synoviocytes-osteoarthritis-hfls-oa\/","title":{"rendered":"Human Fibroblast-Like Synoviocytes-Osteoarthritis (HFLS-OA)"},"content":{"rendered":"

Product Description<\/strong><\/span><\/span><\/p>\n

Synovial joints are unique functional elements of the body and provide the ability for locomotion and for physical interaction with the environment[1,2]. The inner lining of the joint consists of the synovium, also called the synovial membrane, a thin layer located between the joint capsule and the joint cavity. Fibroblast-like synoviocytes (FLS) are mesenchymal origin cells located inside the synovial membrane. FLS display many characteristics common with fibroblasts, such as expression of several types of collagens and protein vimentin, a part of cytoskeletal filament. Once activated, FLS are suggested to acquire a myofibroblast-like phenotype that drives fibrogenesis through excessive extracellular matrix component deposition and an enhanced contractile function. These cells play a crucial role in the pathogenesis of chronic inflammatory diseases, such as rheumatoid arthritis. Therefore, Human FLS are an important model to understand articular function in degenerative and inflammatory joint diseases[1-3].<\/p>\n

iXCells Biotechnologies<\/strong> provides high quality Human Fibroblast-Like Synoviocytes- Osteoarthritis (HFLS-OA), which are isolated from osteoarthritic human synovial membrane and cryopreserved at P2, with \u22650.5 million cells in each vial. HFLS-OA express fibronectin and vimentin and are characterized by their spindle-shaped morphology. They are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast, and fungi and can be further expanded for no more than 3 passages in Synoviocyte Growth Medium (Cat# MD-0056) under the conditions suggested by iXCells Biotechnologies.<\/p>\n

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Figure 1.<\/strong> Human Fibroblast-Like Synoviocytes-Osteoarthritis (HFLS-OA). The cells were recovered, and seeded at 10,000 cells\/cm2<\/sup> following iXCells\u2019 protocol. Phase contrast images were taken at the indicated time post recovery.<\/p>\n

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Figure 2.<\/strong> Immunofluorescence staining with antibodies against Vimentin (green) and Fibronectin (red) of Human Fibroblast-Like Synoviocytes–Osteoarthritis (HFLS-OA).<\/p>\n

 <\/p>\n

Product Details<\/strong><\/p>\n\n\n\n\n\n\n\n\n\n
Tissue<\/strong><\/td>\nHuman synovial membrane<\/td>\n<\/tr>\n
Package Size<\/strong><\/td>\n0.5 million cells\/vial<\/td>\n<\/tr>\n
Passage Number<\/strong><\/td>\nP2<\/td>\n<\/tr>\n
Shipped<\/strong><\/td>\nCryopreserved<\/td>\n<\/tr>\n
Storage<\/strong><\/td>\nLiquid nitrogen<\/td>\n<\/tr>\n
Growth Properties<\/strong><\/td>\nAdherent<\/td>\n<\/tr>\n
Media<\/strong><\/td>\nSynoviocyte Growth Medium (Cat# MD-0056)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

 <\/p>\n

Download Datasheet<\/a>\"\"<\/a>\"\"<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Product Description Synovial joints are unique functional elements of the body and provide the ability for locomotion and for physical interaction with the environment[1,2]. The inner lining of the joint consists of the synovium, also called the synovial membrane, a thin layer located between the joint capsule and the joint cavity. Fibroblast-like synoviocytes (FLS) are […]<\/p>\n","protected":false},"featured_media":122536,"template":"","meta":{"_acf_changed":false,"content-type":"","jetpack_publicize_message":"{title}\n\n{excerpt}\n\n{url}","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"_wpas_customize_per_network":false},"product_brand":[],"product_cat":[1644],"product_tag":[],"cell_type":[2417],"cell_system":[],"organ":[2446],"disease":[2465],"research_area":[],"mutation":[],"mutation_type":[],"disease_model":[],"parental_line_name":[],"class_list":["post-122502","product","type-product","status-publish","has-post-thumbnail","product_cat-human-primary-cells","cell_type-fibroblasts","organ-bone-cartilage-joint","disease-osteoarthritis","first","instock","taxable","shipping-taxable","purchasable","product-type-variable"],"exclude_global_add_ons":[],"addons":[],"acf":[],"yoast_head":"\nHuman Fibroblast-Like Synoviocytes-Osteoarthritis (HFLS-OA) - iXCells<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ixcellsbiotech.com\/product\/human-fibroblast-like-synoviocytes-osteoarthritis-hfls-oa\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Human Fibroblast-Like Synoviocytes-Osteoarthritis (HFLS-OA) - iXCells\" \/>\n<meta property=\"og:description\" content=\"Product Description Synovial joints are unique functional elements of the body and provide the ability for locomotion and for physical interaction with the environment[1,2]. 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