Schwann cells are the principal glia of the peripheral nervous system (PNS). They are responsible for creating myelin sheath that insulates nerve fibers (axons) which are crucial for maintaining nerve health and normal function, and they also support axon regeneration after injury [1]. In vitro cultured Schwann cells are useful tools to study their biology, development, pathophysiology and potential relationship with neurons. These studies involve isolating or differentiating Schwann cells from various sources, including primary PNS tissue or stem cells. Over the past few years, there has been considerable progress in the iPSC derived Schwann cells research. Normal or patient donor specific iPSC-derived Schwann cells offer an attractive experimental platform to study the development of PNS system, model Schwann cells related diseases, and accelerate predictive drug toxicology tests, and advance potential therapies [2]. 

iXCells® Schwann Cell Maintenance Medium (SKU: MD-0124) is a complete medium for iPSC derived Schwann cells culture. It is a serum (low concentration) and antibiotic-antimycotic containing medium, without any additive components required for cell recovery and culture process. The low-serum condition provides the researchers with a more controlled and defined system for the following high-throughput drug testing, tissue engineering, and regenerative medicine research. 

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Media for the low-serum expansion of primary endothelial cells

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Podocytes are terminally differentiated highly specialized epithelial cells that lining the outer surface of the glomerular capillaries in kidney ^[1]. Podocytes together with the opposing monolayers of fenestrated endothelial cells in the vascular space and glomerular basement membrane (GBM) in between form the three-layer glomerular filtration barrier which functions as size-selective and charge-dependent molecular sieve for the main function of nephron. Podocytes injury, which is usually termed “foot process effacement” is a pathological process found in many kidney diseases ^[2]. In vitro cultured podocytes are useful model to study podocytes biology. These cells can also be used with glomerular endothelial cells for coculture studies in an attempt to better study barrier permeability or be cultured in Matrigel for three-dimensional or organoid studies^[3].

iXCells^® Podocytes Culture Medium is a complete medium uniquely designed to maintain primary podocyte growth in vitro. The cells maintain their cell specific markers as well as function for as long as 2-3 passages which makes it suitable for the following cell characterization and functional assays. The medium contains all the necessary nutrients that podocyte needs to grow and perform their function. The medium is provided as the antibiotics free complete culture medium supplemented with the working concentration of fetal bovine serum (FBS). No additional FBS is needed for cell culture.

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GABAergic neurons are a type of neuron that produce gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits nerve transmission and reduces neuronal excitability mainly in hippocampus, thalamus, basal ganglia, hypothalamus, and brainstem ^[1]. The balance between inhibitory neuronal transmission via GABA and excitatory neuronal transmission via glutamate is essential for proper cell membrane stability and neurologic function in central nervous system (CNS). In GABAergic neurons, GABA is primarily synthesized from glutamate, a process catalyzed by glutamate decarboxylase (GAD). GAD, especially the CNS specific 67 kDa subtype GAD67, as well as vesicular GABA neurotransmitter transporter (vGAT) are commonly used cell specific markers for GABAergic neurons ^[2].

iXCells^® GABAergic Neuron Culture Medium is a complete medium uniquely designed to maintain GABAergic neuron growth in vitro and their functions, as measured by the expression of the cell type specific markers along with the electrophysiology activities. The medium is provided as the antibiotics free complete culture medium. No extra glutamine is needed for cell culture.

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iXCells Motor Neuron Activity Medium Kit

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